DNA Methylation Defined

5-methylcytosine (5mC) is a reversible epigenetic mark. In humans and other vertebrates, 5mC is...

Ideal Samples for Validating Next-Generation Sequencing-Based Plasma Circulating Tumor DNA Assays

Over the past decade, liquid biopsy-based testing, especially using next-generation sequencing...

Copy That! Detecting Copy Number Variation in Disease Using Next Generation Sequencing

If one of your colleagues suggests including copy number variations (CNVs) in your assay that...

How to get the most from your Seraseq® FFPE Reference Materials

Most tumor profiling assay workflows use tissue biopsy samples that are formalin fixed and paraffin...

Continued Advances in NIPT Drives Updated Recommendations

Our 2020 blog, Evolution of non-invasive prenatal testing (NIPT), discussed the testing’s history...

When a Bad Repair Leads to a Happy Ending: Homologous Recombination Deficiency Assays for Guiding Anti-Cancer Therapies

Genome instability - in which tumor cells sustain elevated frequencies of chromosomal lesions - is...

Optimal Reference Materials for Evolving Oncology Testing

Targeted therapies are dramatically improving cancer treatment. Next-generation sequencing (NGS)...

Are your BRCA1/2 tests sufficient?

Breast cancer susceptibility genes 1 and 2 (BRCA1 and BRCA2) encode proteins functioning as tumor...